CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).

Dettagli prodotto

• Codice: E-AB-F10750_100μg
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: ≥ 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
• Isotipo: Mouse IgG2b, κ
• Clonalità: Monoclonal
• Clone: IV-3
• Applicazione: FCM
• Simbolo target: FCG;CDw;Fcgr;IGFR;FCGR2B;CD32;CD32B;FCG2;FCGR2;IGFR2;CDw32;Fc-gamma-RIIb;FcRII-b;Low affinity immunoglobulin gamma Fc region receptor II-b;IgG Fc receptor II-b;Fc-gamma RII-b;CD32 antigen;Fc fragment of IgG;Fc gamma receptor IIB;Fc gamma RII;Fc gamma RIIB;FCG2B;Fc-gamma RII;FCRII;FcγRⅡ;IgG Fc receptor II beta;low affinity II;low affinity IIb;Low affinity immunoglobulin gamma Fc region receptor II;Ly-17;Lym 1;Lymphocyte antigen 17;receptor;receptor (CD32);receptor for;receptor for (CD32)
• Area di ricerca: Immunology;Stem Cells