CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.

Dettagli prodotto

• Codice: E-AB-F11130_1mg
• Marca: Elabscience
• Specie target: Mouse
• Host: Rat
• Concentrazione: ≥ 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
• Isotipo: Rat IgG2a, κ
• Clonalità: Monoclonal
• Clone: M18/2
• Applicazione: FCM
• Simbolo target: Integrin beta;ITGB;CD18;Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta;Complement receptor C3 subunit beta;Integrin beta-2;Itgb2;&beta-2 integrin-n
• Area di ricerca: Cell Adhesion;Cell Biology;Immunology;Innate Immunity