B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20‑100 fold higher affinity than CD28 and is involved in the down‑regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages.

Dettagli prodotto

• Codice: E-AB-F12320_5mg
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: ≥ 1 mg/mL
• Link: https://www.elabscience.com/p-af/le_purified_anti_human_cd3ε_antibody[hit3a]-e_ab_f12770
• Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
• Isotipo: Mouse IgG1, κ
• Clonalità: Monoclonal
• Clone: 2D10
• Applicazione: FCM
• Simbolo target: LAB;CTLA-4 counter-receptor B;T-lymphocyte activation antigen CD;B7;B7-1;B7.1;BB1;CD28LG;CD28LG1;LAB7;CD80;CD28LGB7-1 antigen;T-lymphocyte activation antigen CD80;Activation B7-1 antigen;CTLA-4 counter-receptor B7.1; B7-1; BB1;B lymphocyte activation antigen B7;B7-1 antigen;B7-1 antigen);CD28 antigen ligand 1;CD80 antigen;CD80 antigen (CD28 antigen ligand 1;CD80 molecule;Costimulatory factor CD80;costimulatory molecule variant IgV-CD80
• Area di ricerca: Immunology;Stem Cells