CD45, previously called LCA (leukocyte common antigen), T200, or Ly5 in mice, is member C of the class 1 (receptor‑like) protein tyrosine phosphatase family (PTPRC). It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin . Multiple splicing isoforms of exon 4 (A), 5 (B), and 6 (C) are expressed according to cell type, developmental stage and antigenic exposure . The longest form, CD45RABC (called B220 in mouse) is expressed on B lymphocytes, The shortest form, CD45R0, lacking exons 4, 5 and 6 which encode aa 34‑194, is expressed on memory cells, while intermediate sizes are expressed on other T cells.

Dettagli prodotto

• Codice: E-AB-F13720_100μg
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: ≥ 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
• Isotipo: Mouse IgG1, κ
• Clonalità: Monoclonal
• Clone: BC8
• Applicazione: FCM
• Simbolo target: B220;CD45;CD45R;GP180;L-CA;LCA;LY5;T200;PTPRC;CD45 antigen;CD45R0;Ly-5;protein tyrosine phosphatase;receptor type;Receptor-type tyrosine-protein phosphatase C;CD45RO;Receptor-type tyrosine-protein phosphatase CLeukocyte common antigen (L-CA); T200;c polypeptide;CD 45;homolog of;Leukocyte common antigen;loc;Lyt-4;OTTHUMP00000033813;OTTHUMP00000033816;OTTHUMP00000033817;OTTHUMP00000038574;Protein tyrosine phosphatase receptor type c polypeptide;protein tyrosine phosphatase;receptor type;C;receptor type C;T200 glycoprotein;T200 leukocyte common antigen;B220;CD45;CD45 antigen;CD45R;GP180;L-CA;LCA;Ly-5;LY5;Protein tyrosine phosphatase;receptor type;Ptprc;Receptor-type tyrosine-protein phosphatase C;T200
• Area di ricerca: Immunology;Signal Transduction;Neuroscience;Stem Cells;Cardiovascular