The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

Codice: PDMH100218_20μg | Marca: Elabscience | Confezionamento: 20μg

Specie: Human

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Codice: PDMH100218_20μg
Marca: Elabscience
Specie target: Human
Host: Mammalian
Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Simbolo target: CD30L
Ig target: CD153;CD153 antigen;CD30 antigen ligand;CD30 L;CD30 ligand;CD30-L;CD30L;CD30LG;MGC138144;TNFL8;Tnfsf8;Tumor necrosis factor (ligand) superfamily member 8;Tumor necrosis factor ligand superfamily member 8
Area di ricerca: Immunology

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