This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with an other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine-and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with an other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with an hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Dettagli prodotto

• Codice: PDMH100250_1mg
• Marca: Elabscience
• Specie target: Human
• Host: Mammalian
• Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: ACVRL1
• Ig target: Activin A receptor;Activin A receptor type II like 1;Activin A receptor;type II like kinase 1;Activin receptor like kinase 1;Activin receptor-like kinase 1;ACVL1;ACVRL1;ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;Osler Rendu Weber syndrome 2;Serine/threonine protein kinase receptor R3;Serine/threonine-protein kinase receptor R3;SKR3;TGF B superfamily receptor type I;TGF-B superfamily receptor type I;TSR-I;TSR1
• Area di ricerca: Cancer;Cardiovascular;Metabolism;Signal Transduction