Activin A receptor , type II-like 1 (ACVRL1) , also known as ALK-1 (activin receptor-like kinase 1) , is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding , a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney , spleen , heart and intestine , serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2 , also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

Dettagli prodotto

• Codice: PDMH100306_100μg
• Marca: Elabscience
• Specie target: Human
• Host: Mammalian
• Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: ALK-1
• Ig target: SKR;ORW;Activin Receptor-Like Kinase;Serine/Threonine-Protein Kinase Receptor R;ACVRL;ACVRLK;ALK;ACVRL1;ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;SKR3;TSR-I;Activin Receptor-Like Kinase 1;Serine/Threonine-Protein Kinase Receptor R3;TGF-B Superfamily Receptor Type I
• Area di ricerca: Cardiovascular;Signal Transduction;Metabolism