This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Dettagli prodotto

• Codice: AN301268L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 6B9
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:200-1:1000
• Simbolo target: MRE11
• Ig target: MRE;HNGS;MRE11;ATLD;HNGS1;MRE11A;MRE11B;AT like disease;Ataxia telangiectasia disorder like;DNA recombination and repair protein;Double strand break repair protein MRE11A;Double-strand break repair protein MRE11A;endo/exonuclease Mre11;meiotic recombination (S. cerevisiae) 11 homolog A;Meiotic recombination 11 homolog 1;Meiotic recombination 11 homolog A;meiotic recombination 11 homolog A (S. cerevisiae);MmMRE11A;Mre 11;MRE 11a;MRE 11b;MRE11 homolog 1;MRE11 homolog A;MRE11 homolog double strand break repair nuclease;MRE11 meiotic recombination 11 homolog A;MRE11 meiotic recombination 11 homolog A (S. cerevisiae);OTTHUMP00000236830;OTTHUMP00000236831;OTTHUMP00000236832;OTTHUMP00000236833;MRE11
• Area di ricerca: Epigenetics and Nuclear Signaling