Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Dettagli prodotto

• Codice: AN301288L_100μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 0.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: 4D5
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:2000-1:10000
• Simbolo target: Neurofilament
• Ig target: PPP1R;NEFL;CMT1F;CMT2E;NF-L;NF68;NFL;PPP1R110;68 kDa neurofilament protein;CMTDIG;light polypeptide;neurofilament;neurofilament light;FLJ53642;Neurofilament Light Polypeptide;Neurofilament triplet L protein;68kDa Neurofilament;68kDa Neurofilament;CMT1F;CMT2E;FLJ53642;Neurofilament Light Polypeptide;Neurofilament triplet L protein;NFL;NF-L;NF-L
• Area di ricerca: Neuroscience;Signal Transduction;Stem Cells;Developmental Biology