MTAP is an enzyme essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine. MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma, thereby implicating its potential function as a tumor suppressor.

Dettagli prodotto

• Codice: AN301807L_50μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG,κ
• Clonalità: Monoclonal;Recombinant
• Clone: A519
• Coniugazione: Unconjugated
• Applicazione: WB;IHC
• Diluizione: WB 1:1000-1:3000;IHC 1:50-1:100
• Simbolo target: MTAP
• Ig target: HEL;MTAP;BDMF;DMSFH;DMSMFH;HEL-249;LGMBF;MSAP;c86fus;5' methylthioadenosine phosphorylase;5''-methylthioadenosine phosphorylase;Epididymis luminal protein 249;HEL 249;MeSAdo phosphorylase;Methylthioadenosine phosphorylase;MTA phosphorylase;MTAPase;S methyl 5 thioadenosine phosphorylase;S methyl 5' thioadenosine phosphorylase;S-methyl-5''-thioadenosine phosphorylase
• Area di ricerca: Signal Transduction;Metabolism