The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

Dettagli prodotto

• Codice: E-AB-10700_60μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.3 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:2000
• Simbolo target: ALKBH2
• Ig target: 2OG Fe(II) oxy DC1;9530023G02;ABH 2;ABH2;alkB alkylation repair homolog 2;ALKB2;ALKBH2 alkB;ALKBH2;Alkylated DNA repair protein alkB homolog;Alkylated DNA repair protein alkB homolog 2;Alkylation repair homolog 2;Alpha ketoglutarate dependent dioxygenase alkB homolog 2;Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2;AU016977;DNA oxidative demethylase ALKBH2;EC 1.14.11.;FLJ99103;hABH2;mABH2;MGC90512;Oxy DC1
• Area di ricerca: Epigenetics and Nuclear Signaling