Activating signal co-integrator-1 (ASC-1), originally identified as TRIP4, is a transcriptional co-activator of nuclear receptors that associates with specific components of the RNA polymerase II complex and binds the basal transcription factors TBP and TFIIA. ASC-1 functions with the transcription integrators SRC-1 and CBP/p300 through its zinc finger motif and is dependent on their ligand-dependent transactivation domain, AF2. Endogenous ASC-1 in HeLa cells is predominantly a nuclear protein. Under conditions of serum starvation, ASC-1 localizes to the cytoplasm.

Dettagli prodotto

• Codice: E-AB-10962_20μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.5 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:50-1:200
• Simbolo target: TRIP4
• Ig target: Activating signal cointegrator 1;ASC 1;ASC-1;HsT17391;Thyroid hormone receptor interactor 4;Thyroid receptor interacting protein 4;Thyroid receptor-interacting protein 4;TR-interacting protein 4;TRIP 4;TRIP-4;Trip4;TRIP4;ZC2HC5;Zinc finger C2HC5 type
• Area di ricerca: Epigenetics and Nuclear Signaling