Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity.

Dettagli prodotto

• Codice: E-AB-53394_200μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 1.2 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:2000
• Simbolo target: MAFA
• Ig target: HMafA;Mafa;MAFA;Pancreatic beta cell specific transcriptional activator;Pancreatic beta-cell-specific transcriptional activator;RIPE3b1;Transcription factor MafA;Transcription factor RIPE3b1;v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian);v maf musculoaponeurotic fibrosarcoma oncogene homolog A;V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
• Area di ricerca: Cancer;Epigenetics and Nuclear Signaling;Signal transduction