Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).

Dettagli prodotto

• Codice: E-AB-70180_60μL
• Marca: Elabscience
• Specie target: Human;Mouse;Rat
• Host: Rabbit
• Concentrazione: 210 μg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: WB
• Diluizione: WB 1:500-1:1000
• Simbolo target: CD156c
• Ig target: A disintegrin and metalloprotease domain 10;A disintegrin and metalloproteinase domain 10;AD 10;AD10;AD18;ADA10;ADAM 10;ADAM metallopeptidase domain 10;ADAM10;CD 156c;CD156c;CD156c antigen;CDw156;disintegrin and metalloproteinase domain containing protein 10;Disintegrin and metalloproteinase domain-containing protein 10;HsT 18717;HsT18717;Kuz;Kuzbanian;Kuzbanian protein homolog;Kuzbanian;Drosophila;homolog of;MADM;Mammalian disintegrin metalloprotease;Mammalian disintegrin-metalloprotease;RAK
• Area di ricerca: Cancer;Cell Biology;Signal Transduction