Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
ADD2 Antibody detects endogenous levels of total ADD2.
ADD3 Antibody detects endogenous levels of total ADD3.
Adenosine is an endogenous nucleoside distributed throughout human cells. It can directly enter the myocardium and be phosphorylated to produce adenosine, which is involved in myocardial energy metabolism, and also participates in the dilation of coronary vessels and increase blood flow. Adenosine has physiological effects on the cardiovascular system and many other systems and tissues of the body. It also promotes the growth of human hair follicles and the proliferation of dermal papilla cells in vitro. The detection principle of this kit is that the substances produced by the enzyme-catalyzed adenosine reaction consume NADH, the OD value of the system decreases at 340 nm, and the content of adenosine can be calculated by calculating the decline rate at 340 nm.
Adenosine deaminase (ADA) can hydrolyzed the substrate adenosine to form hypoxanthine riboside, which is hydrolyzed by purine riboside phosphatase to produce hypoxanthine and phosphate ribose. Under the action of xanthine oxidase, hypoxanthine produces hydrogen peroxide, which produces red substance under the action of peroxidase, 4-aminotepyrine and color source. The red substance has the maximum absorption peak at 550 nm and the changes of absorbance is proportional to the activity of ADA.
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