A synthesized peptide derived from human AFP, corresponding to a region within C-terminal amino acids.
Alpha-fetoprotein (AFP) is a glycoprotein normally expressed in the fetal liver and yolk sac endoderm. It can be used to label hepatocellular carcinoma and a variety of germ cell tumors, such as yolk sac tumors of the testis and ovary. In the diagnosis of hepatocellular carcinoma, the sensitivity of AFP is low, but the specificity is high, so it can be used in combination with other antibodies in the diagnosis of hepatocellular carcinoma.
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Alpha-fetoprotein (AFP) is a glycoprotein that is normally expressed in fetal liver and yolk sac endoderm. It can be used to mark hepatocellular carcinoma and a variety of germ cell tumors, such as yolk sac tumors of testis and ovaries. In the diagnosis of hepatocellular carcinoma, AFP has low sensitivity but high specificity, so it can be used in combination with other antibodies in the diagnosis of hepatocellular carcinoma.
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