A synthesized peptide derived from human ABCC2, corresponding to a region within the internal amino acids.
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
A synthetic peptide from human ABCC2
A synthesized peptide derived from human ABCC3, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human ABCC4, corresponding to a region within N-terminal amino acids.
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