Thyroglobulin(TG) is a 330 kDa glycoprotein synthesized by thyroid follicles and expressed in normal thyroid follicular epithelium and glia, thyroid follicular adenoma, thyroid follicular carcinoma and papillary carcinoma. Thyroglobulin(TG) Monoclonal has high tissue specificity and is mainly used in the study of various types of primary and metastatic thyroid follicular epithelial carcinoma. It is a specific marker of normal thyroid tissue and benign and malignant thyroid tumors.
Topo Ⅱ is an endonuclease and a target molecule of some tumor drugs. At the same time, it is related to signal transduction, cell proliferation and apoptosis. The higher the expression level of Topo Ⅱ, the higher the sensitivity to tumor drugs. At present, it is mostly used in the study of drug resistance of tumor.
Thyroid peroxidase (TPO) is located on the apical free surface of thyroid epithelial cells. TPO oxidize iodine ions to form iodine atoms, which are added to the tyrosine residues of thyroglobulin to produce thyroxine. It is a key enzyme in thyroid hormone synthesis. TPO is widely expressed in normal thyroid and benign thyroid lesions, and its expression is reduced in thyroid cancer. It can be used to distinguish benign and malignant thyroid tumors, but its specificity and sensitivity are not high.
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