CD21, also known as complement receptor type 2 (CR2) and Epstein-Barr virus receptor, is expressed on follicular dendritic cells (FDCS) and B lymphocytes. It can be used to show the FDC network in the follicle and understand whether the lymph node structure is destroyed. Follicular dendritic cell sarcoma was positive for CD21. CD21 can also be used to identify abnormal follicular dendritic cell patterns in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.
CD23 is a kind of transmembrane glycoprotein expressed in a variety of hematopoietic cells. It is expressed in some mature B-cell lymphoma and Hodgkin's lymphoma R-S cells. Most of CLL / SLL are CD23 positive, while mantle cell lymphoma is usually CD23 negative.
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