Alpha-methylacyl-CoA racemase (AMACR), also known as P504S, is a mitochondrial and peroxisome enzyme. AMACR is expressed in normal liver (hepatocyte), kidney (tubular epithelial cell) and gallbladder (epithelial cell). AMACR is also expressed in Lung (bronchial epithelial cells) and colon (surface epithelium of colon). AMACR is a specific marker of prostate cancer.
Annexin A1 is a member of calcium dependent phospholipid binding protein superfamily, which is widely expresseded in human tissues. It is an endogenous anti-inflammatory medium, which plays a role in innate and adaptive immunity by controlling the biosynthesis of inflammation, prostaglandin and leukotriene mediators. Annexin A1 can be used to distinguish leukemia from other B-cell lymphoma. The overexpression of Annexin A1 is also frequently found in adenocarcinoma of the esophageal and gastroesophageal junction, which is related to pathological T stage and distal metastasis, and is an independent prognostic indicator.
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