Cytokeratin 20 (CK20) with a molecular weight of 46 kDa, it is mainly expressed in gastrointestinal epithelium, urinary epithelium and Merkel cells. Cytokeratin 19 Monoclonal is mainly used in the judging of gastrointestinal adenocarcinoma, ovarian mucinous tumor and Merkel cell carcinoma. CK20 is not expressed in squamous cell carcinoma, breast cancer, lung cancer, endometrial cancer and non-mucinous ovarian cancer.
Cytokeratin 5/6 (CK5/6) is a high molecular weight cytokeratin (58 kDa and 56kDa). In normal tissues, basal cells of squamous and ductal epithelium and some basal cells, myoepithelial cells and mesothelial cells of squamous epithelium were positive, while glandular epithelial cells were negative. CK5/6 has been shown to be expressed in the vast majority of squamous cell carcinomas, basal cell carcinomas, thymomas, salivary gland tumors, and mesotheliomas, but rarely reacts with lung adenocarcinomas. It is mainly used in the differential diagnosis of mesothelioma and adenocarcinoma, and can be used in the differential diagnosis of benign and malignant prostate lesions when combined with 34βE12 and P504S.
Cytokeratin 5 (CK5) is related to cytokeratin 6. They have similar tissue distribution and present in different proportions in many non-keratinized stratified squamous epithelium, such as tongue mucosa, tracheal basal epithelium, epidermal basal cells, hair follicles, skin sebaceous glands and sweat glands, breast cavity cells, prostate basal cells, urethral epithelial cells, vaginal and cervical endometrial mucosa. Cytokeratin 5 and Cytokeratin 6 are also expressed in basal cell epithelioma, cutaneous squamous cell carcinoma, tongue, epiglottis and rectoanal region.
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