DOG1 is a calcium-dependent chloride channel encoded by the TMEM16A gene and is localized on chromosome 11q13. "DOG1 is expressed in cells of Cajal in the gastrointestinal tract, in acinar cells of the salivary gland (with apical membrane staining, especially serous cells), in acinar central cells of the pancreas, in hepatocytes, and in epithelial cells of the biliary tract, breast, stomach, and prostate." DOG1 is selectively expressed in gastrointestinal stromal tumors. Approximately 87% of gastrointestinal stromal tumors express DOG1. It is occasionally expressed in synovial sarcoma, leiomyosarcoma, etc.
Cadherin is a kind of transmembrane glycoprotein which mediates the adhesion between cells. There are more than 30 subtypes such as e -, N -, P -, etc. the loss of cadherin's function can cause the destruction of cell-cell connection. At present, it is mainly used in the study of invasion and metastasis of various malignant tumor cells.
Lascia la tua email e seleziona le aree che vuoi seguire per ricevere novita di prodotto, approfondimenti tecnici e promozioni piu pertinenti.
Puoi scegliere le macro-aree Life Science e Diagnostica oppure le singole specializzazioni.
Seleziona uno o piu ambiti di interesse per ricevere comunicazioni piu utili e mirate.
Aggiornamenti su ricerca, strumentazione e applicazioni per il mondo Life Science.
Novita, approfondimenti e promozioni per laboratori diagnostici e flussi operativi.
2025 TEMA Ricerca - All Rights Reserved.