Androgen receptor (AR) plays an important role in the development of prostate cancer. The positive expression of AR is related to the degree of prostate cancer tissue differentiation, and the patients with AR have significant effect on anti-hormone therapy. It is mainly used to detect prostate cancer and guide the treatment. At present, it can also be used in the research of breast cancer, esophageal cancer and other malignant tumors. Androgen receptor (AR) is highly expressed in well differentiated tumors, but low or no expression in poorly differentiated tumors.
BCL2 is a protein that regulates apoptosis by controlling mitochondrial permeability and the release of cytochrome c1. Overexpression of BCL2 promotes cell survival by inhibiting apoptosis, which has been found to be associated with poor prognosis in breast, prostate, ovarian, endometrial and colon cancers. In normal lymphoid tissues, BCL2 antibodies label many cells in the small B-lymphocytes and T-cell regions of the mantle. BCL2 has great value in distinguishing the reactivity and tumor follicular proliferation in lymphoid injury.
BCL-6 is a proto-oncogene encoding the 95kDa Kruppel type zinc finger protein, which is homologous to other transcription factors. BCL-6 is expressed in normal follicular germinal center B cells and other associated lymphomas. BCL-6 expression can be detected in follicular lymphoma, diffuse large B-cell lymphoma, Burkitt lymphoma, and nodular lymphocyte-dominated Hodgkin's lymphoma. Positive expression of BCL-6 can be detected when splenic marginal band lymphomas transform into diffuse large B-cell lymphomas, and positive expression can also be detected in vascular immunoblastic T-cell lymphomas. In addition, it should be noted that many normal T cells also express BCL-6.
BCL-6 is a proto-oncogene encoding a 95kDa Kruppel-type zinc finger protein with homology to other transcription factors. BCL-6 is expressed in normal follicular germinal center B cells and other related lymphomas. The expression of BCL-6 was detected in follicular lymphoma, diffuse large B-cell lymphoma, Burkitt's lymphoma and nodular lymphocytic Hodgkin's lymphoma. When splenic marginal zone lymphoma transformed into diffuse large B-cell lymphoma, BCL-6 expression was also detected in angioimmunoblastic T-cell lymphoma. In addition, it should be noted that many normal T cells also express BCL-6.
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