BCL-6 is a proto-oncogene encoding a 95kDa Kruppel-type zinc finger protein with homology to other transcription factors. BCL-6 is expressed in normal follicular germinal center B cells and other related lymphomas. The expression of BCL-6 was detected in follicular lymphoma, diffuse large B-cell lymphoma, Burkitt's lymphoma and nodular lymphocytic Hodgkin's lymphoma. When splenic marginal zone lymphoma transformed into diffuse large B-cell lymphoma, BCL-6 expression was also detected in angioimmunoblastic T-cell lymphoma. In addition, it should be noted that many normal T cells also express BCL-6.
Catenin is a cytoskeleton protein, which has three subtypes of ex, P and Y. It has two functions: signal conduction and cell adhesion. It is mainly used in the study of metastasis and infiltration mechanism of various malignant tumors such as colon cancer, lung cancer, prostate cancer, esophageal cancer, breast cancer, etc.
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