HSP70, a member of the heat shock protein family, is associated with cell division, apoptosis, and tumorigenesis. Studies have found that the expression of HSP70 may be related to the occurrence, development and prognosis of tumors. HSP70 antibodies also directly inhibit apoptosis and have been shown to be involved in the protective effects against heat stress and cytotoxic drugs. HSP70 is upregulated in HCC and is often used in HCC studies together with Glypican-3.
The IDH1 gene is located at 2q33 and encodes isocitrate dehydrogenase 1. Heterozygous point mutations at codon 132 of IDH1 frequently occur in WHO grade Ⅱ and Ⅲ gliomas. IDH1 gene mutation is somatic cell specific and only occurs in some subtypes of gliomas, which can be used as a basis for glioma subtyping. Heterozygous IDH1 mutation at position 132 occurs in more than 80% of low-grade gliomas, including astrocytoma, oligodendroglioma, oligodendroastrocytoma and secondary glioblastomas. Further studies have shown that the prognosis of IDH1 mutation is significantly better than that of wild type. Therefore, the identification of IDH1 gene mutation is an important reference index for pathological diagnosis and prognosis evaluation.
Immunoglobulin A (IgA) reacts with the A-chain of immunoglobulin IgA, an antibody that plays a key role in mucosal immune function. It has a certain auxiliary significance in the differential diagnosis of plasmacytoma and lymphoplasmacytic lymphoma, and can also be used for the functional classification of glomerulonephritis.
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