Immunoglobulin A (IgA) reacts with the A-chain of immunoglobulin IgA, an antibody that plays a key role in mucosal immune function. It has a certain auxiliary significance in the differential diagnosis of plasmacytoma and lymphoplasmacytic lymphoma, and can also be used for the functional classification of glomerulonephritis.
The antibody reacts with the delta chain of IgD and is a marker of B cell development and maturation. It has an auxiliary role in the determination of leukemia cells and the classification of lymphoma.
IgG antibodies are large globular proteins composed of four peptide chains with a molecular weight of about 150kDa. "It contains two identical heavy chains of about 50kDa(γ) and two identical light chains of about 25kDa and is therefore a tetrameric quaternary structure." Studies have shown that IgG antibodies can be used to evaluate renal biopsies, autoimmune diseases, and to identify plasma cell tumors and non-Hodgkin's lymphoma.
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