Neurofilament(NF) is a neuron specific intermediate filament protein, which is a polymer composed of three subunits of different molecular weight. It is expressed in central, peripheral neurons and tumors in different proportions. Its mainly expressed in ganglioneuroma, paraganglioma, cerebellum or peripheral neuroblastoma, adrenal tumor or peripheral pheochromocytoma, which is helpful for the judging of neuroblastoma and pheochromocytoma And differential diagnosis.
NKX3.1 is an androgen-regulated homeobox gene specifically expressed in prostate cells. It is mainly localized in the prostatic epithelium, but is also present in the testis, ureter, and bronchial mucous glands of the lung. As a transcription factor, it has a key role in prostate development and tumor suppression. It is a negative regulator of epithelial cell growth in prostate tissue. NKX3.1 has a high sensitivity and specificity in tumors of prostate epithelial origin. It is not expressed in bladder cancer and nephrogenic tumors and can be used for the differential diagnosis of prostate cancer.
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