p40 is one of the subtypes of p63 protein. p63 is widely used in the classification of lung cancer in daily pathological diagnosis. It has a high sensitivity in lung squamous cell carcinoma, but it is also partially expressed in lung adenocarcinoma. Therefore, p40 is recommended for the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma.
P53 is a tumor suppressor gene, which can be divided into wild type and mutant type. P53 is expressed in many kinds of tumors, including breast tumors, gastrointestinal tumors, liver cell tumors and respiratory tumors. The mutation or deletion of the gene is the cause of many tumors. P53 is also a regulator of apoptosis. The expression of P53 is mainly used in the study of various tumors and can be used as one of the indicators of tumor prognosis.
P57 is a cell cycle suppressor and tumor suppressor, which is mainly located on maternal chromosome 11. In complete hydatidiform mole, there is no maternal gene, and p57 is negative, while in partial hydatidiform mole, there are genes of both parents, and p57 is positive. So p57 can be used as a marker for judging and differential judging of early hydatidiform mole pregnancy.
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