Pax-2 is a member of Pax transcription factor family. Pax-8 and Pax-2 participate in the formation of renal organs. In non-tumor tissues, Pax-2 is expressed in glomerular wall epithelial cells, renal collecting duct cells, atrophic renal tubular cells, ovarian surface epithelial cells, fallopian tubes, endometrium, endometrium. In primary tumors, Pax-2 is mainly expressed in renal cell carcinoma and nephrogenic tumor. Recent studies have shown that Pax-2 can be used as an effective immunohistochemical marker for the judging of renal epithelial cell tumors and some gynecological tumors.
B cell line specific activator protein (BASP, Pax-5). In the early stage of B cell development, Pax-5 can affect the expression of CD19, CD20 and other B cell specific genes. The protein plays an important role in the development of B cells and neurons. It is mainly expressed in the nucleus of pre-B cells and mature B cells, but not expressed in plasma cells, it is weak expression of R-S cells in Hodgkin's lymphoma and negative expression of T cells and tumors from which they are derived. It is mainly used for the judging of B cells and tumors from which they are derived.
Pax-8 is a member of the Pax family of transcription factors, which plays a key role in fetal development and cancer growth. Pax-8 is involved in renal cell differentiation, thyroid development, or thyroid dysgenesis. For metastatic RCC, Pax-8 was more sensitive than CD10 and RCC. Existing studies have found that Pax-8 is expressed in some subtypes of kidney, bladder and thyroid tumors and ovarian malignant tumors, but not in most epithelial tumors such as breast cancer, lung cancer and malignant mesothelioma. It can be used to distinguish primary renal epithelial tumors from metastatic tumors and ovarian serous carcinoma from mucinous carcinoma and mesothelioma.
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