This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin.
A synthesized peptide derived from human N-WASP, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NXF1, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human NXF2, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human NXF3, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human NXF5.
A synthesized peptide derived from human NXN, corresponding to a region within N-terminal amino acids.
Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP.
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