A synthesized peptide derived from human Occludin, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human Occludin, corresponding to a region within C-terminal amino acids.
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
A synthetic peptide from human Occludin
A synthesized peptide derived from human OCIAD1, corresponding to a region within the internal amino acids.
Occludin is an integral membrane protein located at the tight junction. It is a tetraspanin protein with four transmembrane domains,intracellular N and C termini and two extracellular loops. Occludin plays a role in the formation and regulation of the tight junction paracellular permeability barrier. Occludin can exist in different isoforms,owing to modifications at the posttranscriptional and posttranslational levels .
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. Acts as a coreceptor for hepatitis C virus (HCV) in hepatocytes.
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