Arginase-1 is encoded by ATG1 gene, it is a key urea cycle metalloenzyme. Arginase-1 has a high specific expression in normal human liver, which is a sensitive and specific index of benign and malignant hepatocytes. In normal liver, there is no response in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells or vascular endothelial cells.
Arginase 1, also known as liver arginase, is a binuclear manganese metalloenzyme. It is a key enzyme of the urea cycle that catalyses the conversion of L-arginine into L-ornithine and urea, the final cytosolic reaction of urea formation in the mammalian liver . Arginase 1 is abundantly expressed in liver, but it is also expressed in cells and tissues that lack a complete urea cycle, including lung.
Arginase is a key enzyme in the urea cycle. Arginase plays an important role in tumor, cardiovascular disease and so on. The principle of this kit is that arginase catalyzes substrate decomposition to produce urea, and urea reacts with chromogenic agent to produce chromogenic substance. The optimal detection wavelength of this product is 520 nm. By detecting the amount of chromogenic substance produced per unit time, the activity of arginase in the sample can be calculated.
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