This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus.
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle,it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol,and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.
A synthesized peptide derived from human ASUN, corresponding to a region within C-terminal amino acids.
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