CD200 is a transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. It contains one Ig like V type domain and one Ig like C2 type domain in its extracelluar domain. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells; basophils; macrophages; and dendritic cells; which suggests myeloid cell regulation as the major function of CD200. CD200 and CD200R associate via their respective N-terminal Ig-like domains. In myeloid cells; CD200R initiates inhibitory signals following receptor-ligand contact. In T cells; CD200 functions as a co-stimulatory molecule independent of the CD28 pathway. In addition; CD200 also plays an important role in prevention of graft rejection; autoimmune diseases and spontaneous abortion.
OX40; also termed CD134 and TNFRSF4; is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions; including cytokine production; expansion; and survival; are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance; peripheral T-cell homeostasis; and T-cell-mediated inflammatory diseases.
OX40;also termed CD134 and TNFRSF4; is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions; including cytokine production; expansion; and survival; are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance; peripheral T-cell homeostasis; and T-cell-mediated inflammatory diseases.
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
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