A synthesized peptide derived from human SGK1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human SGK1, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human SGK1.
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
A synthetic peptide from human SGK1
A synthesized peptide derived from human SGK269, corresponding to a region within the internal amino acids.
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