CD105 is a kind of cell membrane protein in TGF-P receptor signal transduction, and it is also a proliferation related antigen of vascular endothelial cells. It is mainly used in the study of angiogenesis in various malignant tumor tissues.
CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), which is expressed in bone marrow hematopoietic stem cells (including neutrophils), follicular centroblasts, some mature B lymphocytes and parafollicular T lymphocytes. CD10 is also found in the upper layer of intestinal brush border cells, liver cholangiocarcinoma，glomeruli and renal tubular cells,alveolar cells, myoepithelial cells, breast, sweat gland,salivary gland,prostate cells and a small number of fibroblasts. CD10 is expressed in most acute lymphoblastic leukemia, follicular lymphoma and Burkitt's lymphoma. CD10 can be specifically used for the identification and classification of B-cell leukemia/lymphoma and other tumors, such as hepatocellular carcinoma and renal cell carcinoma.
CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), is a single-chain cell surface glycoprotein with a molecular weight of 110 kDa. It is present on the cell surface of bone marrow stem cells and bone marrow cells (including neutrophils), follicular central cells, a few mature B lymphocytes, and a subset of parafollicular T lymphocytes. In addition, CD10 could be detected in the fluid of the upper gut (brush border), liver (bile ducts), kidney (glomerular and proximal tubular cells), alveolar cells, myoepithelial and salivary glands of the mammary gland and sweat glands, prostatic cells, and a small number of fibroblasts. "CD10 is expressed in most B-lymphoblastic leukemia-lymphomas, follicular lymphomas, and Burkitt lymphomas, whereas mantle cell lymphomas and marginal zone lymphomas are usually negative." Among the non-hemolymphatic tumors, CD10 can also be used in the differential diagnosis of endometrial stromal sarcoma (+) and smooth muscle tumor (-), as well as in the differential diagnosis of hepatocellular carcinoma and renal cell carcinoma.
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