This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
A synthesized peptide derived from human OSBL6, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human OSBP, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human OSBPL10, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human OSBPL11.
A synthesized peptide derived from human OSBPL2, corresponding to a region within C-terminal amino acids.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
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