This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
A synthesized peptide derived from Human OSBPL5.
A synthesized peptide derived from human OSBP, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human OSCAR.
A synthesized peptide derived from Human OSCP1.
A synthesized peptide derived from human OSGEPL1.
A synthesized peptide derived from human OSGI1, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human OSM.
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.
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