The SF1-1.1 antibody reacts with the H-2Kd MHC class I alloantigens expressed on nucleated cells from mice of the H-2Kd haplotype. H-2Kd is involved in antigen presentation to T cells expressing CD3/TCR and CD8 proteins.
These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.
The NKG2 molecules are a family of lectin-like receptors that form heterodimers with CD94. NKG2/CD94 heterodimer are primarily expressed on NK cells, and a subset of CD8+ T cells. Studies of CD94/NKG2 heterodimers on NK cells have demonstrated that the NKG2 components transduce signals after ligand binding. NKG2A transduces inhibitory signals, while NKG2C and NKG2E transduce activating signals.
CD29 is a 130 kD protein, also known as integrin β1, VLA-β chain, or GPIIa. It is a member of the integrin family, expressed broadly on leukocytes, endothelial cells, smooth muscle, and epithelial cells. In association with CD49a-f, CD29 forms the VLA-1 through VLA-6 complexes, respectively. It plays an important role in cell-cell or cell-matrix interaction. The HMß1-1 antibody reacts with both mouse and rat CD29. It is able to block cell adhesion and inhibit T cell proliferation.
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