A synthesized peptide derived from human S100A3, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human S100A4, corresponding to a region within C-terminal amino acids.
S-100A4 protein is an important member of S100 family. As an angiogenic factor, S-100A4 protein can enhance the mobility of endothelial cells, reduce the production of angiogenesis inhibitors, and promote the development of blood vessels, tumor invasion and metastasis.
S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.
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