Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.
A synthesized peptide derived from human SCN1B, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human SCN2B, corresponding to a region within the internal amino acids.
A synthesized peptide derived from Human SCN3B.
A synthesized peptide derived from human SCN4A, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human SCN4B, corresponding to a region within C-terminal amino acids.
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
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