NAP1L1 (Nucleosome assembly protein 1-like 1; NAP1-Related Protein, NRP) is a member of the NAP family of histone chaperones. Histone chaperones are involved in chromatin assembly following DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation.
May be involved in actively transporting phosphate into cells via Na+ cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.
Napsin A (aspartic protease A) belongs to the class of endopeptidases, which is mainly expressed in adult lungs (type II lung cells), kidneys and fetal lungs, and is low in adult spleen and peripheral blood leukocytes. Napsin A may be involved in the processing of lung cell surfactant precursors. Napsin A is expressed in more than 90% of primary lung adenocarcinoma, but not in other malignant tumors, so it can be used as a potential marker for primary lung adenocarcinoma.
NAT-10 (N-acetyltransferase 10) is a nuclear protein that belongs to the UPF0202 family. It has a single N-acetyltransferase domain that likely functions as a histone acetyltransferase. NAT10 functions primarily to regulate the activity of telomerase. It is upregulated in response to DNA damage and is likely to take part in genotoxic resistance and DNA repair. NAT-10 has a high binding potential for the promoter region of TERT which stimulates the production of telomerase. These varieties of function imply that human telomerase complexes have multiple functions rather than specific duties.
The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome.
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Inserisci la tua e-mail e seleziona le aree di interesse per ricevere le ultime novità, approfondimenti e promozioni.
Seleziona uno o più ambiti di interesse per ricevere comunicazioni più utili e mirate.
2025 TEMA Ricerca - All Rights Reserved.
