Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.
A synthesized peptide derived from human SQRDL, corresponding to a region within the internal amino acids.
Purified recombinant fragment of human SQSTM1 (AA: 232-356) expressed in E. Coli.
A synthesized peptide derived from human SQSTM1/p62, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human SQSTM1/p62, corresponding to a region within the internal amino acids.
A synthetic peptide from human SQSTM1
Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
Inserisci la tua e-mail e seleziona le aree di interesse per ricevere le ultime novità, approfondimenti e promozioni.
Seleziona uno o più ambiti di interesse per ricevere comunicazioni più utili e mirate.
2025 TEMA Ricerca - All Rights Reserved.
