Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
Squalene synthase (SQS) is involved in the isoprene biosynthesis pathway, and its catalytic action is the first rate-limiting step in sterol biosynthesis. Squalene synthetase can produce squalene under the co-action of cofactors. The principle of this kit is that the absorbance of cofactors can be measured at 340 nm, and the amount of cofactors consumed in the catalytic reaction is proportional to the activity of squalene synthase, and the activity of squalene synthase can be calculated according to the change of absorbance value per unit time.
The Squirrel Monkey IFN beta yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Squirrel Monkey IFN beta applications are for cell culture, ELISA standard, and Western Blot Control. Squirrel Monkey IFN beta yeast-derived recombinant protein can be purchased in multiple sizes. Squirrel Monkey IFN beta Specifications: (Molecular Weight: 20.0 kDa) (Amino Acid Sequence: MSYNLLGFLQ RRSNFQSQKL LRQLNGRLEY CLKDRMDFEI PKEITQPQRL QKEDVALIVY EMLQNIFTIF NRDFSRTGWN KTIVENFLAN VYQHIEHLKT ILKEKWEKKE FTREKSMSSL HLKRYYGRIL HYLMAKEYSH CAWTIVSAEI LRNFYFIDRL TGYL (164)) (Gene ID: 101035681). For research use only. Made in the USA
A synthesized peptide derived from Human SRA1.
C82H142N28O22
SLTARHKILHRLLQEG
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