ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
Acetaldehyde is the main aldehyde compound in fermented food such as beer and wine, and has pungent odor. At present, acetaldehyde can be used as a food additive in yogurt, juice, candy, and alcoholic beverages, and it is generally believed that acetaldehyde ingestion from normal drinking in daily life will not cause cancer. However, more and more recent studies have found that acetaldehyde produced in the human body through the pathway of ethanol metabolism will increase the probability of human cancer. The detection principle of this kit is: The enzyme catalyzes acetaldehyde to product an orange-red substance with the chromogenic agent. The maximum absorption of the substance is at 450 nm, and the content of acetaldehyde in the sample can be calculated by measuring the OD value at 450 nm.
C44H66N14O7S2
Ac-RFMWMR-NH2
C42H61N114O8S2
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